abstract：:Mutations in fused in sarcoma and/or translocated in liposarcoma (FUS, TLS or FUS) are linked to familial cases of amyotrophic lateral sclerosis (ALS). Mutant FUS selectively accumulates into discrete cytosolic structures known as stress granules under various stress conditions. In addition, mutant FUS expression can ...

journal_title：Neurobiology of aging

authors： Matus S,Bosco DA,Hetz C

更新日期：2014-12-01 00:00:00

abstract：:Differential cell death is a common feature of aging and age-related disease. In the retina, 30% of rod photoreceptors are lost over life in humans and rodents. However, studies have failed to show age-related cell death in mouse cone photoreceptors, which is surprising because cone physiological function declines wit...

journal_title：Neurobiology of aging

authors： Cunea A,Powner MB,Jeffery G

更新日期：2014-11-01 00:00:00

abstract：:Increased mitochondrial hydrogen peroxide (H2O2) is associated with Alzheimer's disease and brain aging. Peroxiredoxin 3 (Prdx3) is the key mitochondrial antioxidant defense enzyme in detoxifying H2O2. To investigate the importance of mitochondrial H2O2 in age-associated cognitive decline, we compared cognition betwee...

journal_title：Neurobiology of aging

authors： Chen L,Na R,Ran Q

更新日期：2014-11-01 00:00:00

abstract：:In Alzheimer's disease (AD), amyloid-β (Aβ) deposits accumulate in the brain parenchyma and contain fibrils of aggregated heterogeneous Aβ peptides. In addition to fibrils, Aβ aggregates into stable soluble species (termed Aβ oligomers), which are increasingly viewed as the key drivers of early neurodegenerative event...

journal_title：Neurobiology of aging

authors： Ferrera D,Mazzaro N,Canale C,Gasparini L

更新日期：2014-11-01 00:00:00

abstract：:Cortico-striatal-thalamic network functional connectivity (FC) and its relationship with levodopa (L-dopa) were investigated in 69 patients with hemiparkinsonism (25 drug-naïve [n-PD] and 44 under stable/optimized dopaminergic treatment [t-PD]) and 27 controls. Relative to controls, n-PD patients showed an increased F...

journal_title：Neurobiology of aging

authors： Agosta F,Caso F,Stankovic I,Inuggi A,Petrovic I,Svetel M,Kostic VS,Filippi M

更新日期：2014-11-01 00:00:00

abstract：:TREM2 mutations were first identified in Nasu-Hakola disease, a rare autosomal recessive disease characterized by recurrent fractures because of bone cysts and presenile dementia. Recently, homozygous and compound heterozygous TREM2 mutations were identified in rare families with frontotemporal lobar degeneration (FTL...

journal_title：Neurobiology of aging

authors： Le Ber I,De Septenville A,Guerreiro R,Bras J,Camuzat A,Caroppo P,Lattante S,Couarch P,Kabashi E,Bouya-Ahmed K,Dubois B,Brice A

更新日期：2014-10-01 00:00:00

abstract：:Our objective was to examine associations between glucose metabolism, as measured by (18)F-fluorodeoxyglucose positron emission tomography (FDG PET), and age and to evaluate the impact of carriage of an apolipoprotein E (APOE) ε4 allele on glucose metabolism and on the associations between glucose metabolism and age. ...

journal_title：Neurobiology of aging

authors： Knopman DS,Jack CR Jr,Wiste HJ,Lundt ES,Weigand SD,Vemuri P,Lowe VJ,Kantarci K,Gunter JL,Senjem ML,Mielke MM,Roberts RO,Boeve BF,Petersen RC

更新日期：2014-09-01 00:00:00

abstract：:Cerebral gray-matter volume (GMV) decreases in normal aging but the extent of the decrease may be experience-dependent. Bilingualism may be one protective factor and in this article we examine its potential protective effect on GMV in a region that shows strong age-related decreases-the left anterior temporal pole. Th...

journal_title：Neurobiology of aging

authors： Abutalebi J,Canini M,Della Rosa PA,Sheung LP,Green DW,Weekes BS

更新日期：2014-09-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP expression in postmortem human AD and triple transgenic mouse (3xTG, Psen1/APPSwe/TauP301L) brains. We established an in vitro model of primary neurona...

journal_title：Neurobiology of aging

authors： Han P,Tang Z,Yin J,Maalouf M,Beach TG,Reiman EM,Shi J

更新日期：2014-09-01 00:00:00

abstract：:The knowledge base of nutrition and the brain is steadily expanding. Much of the research is aimed at ways to protect the brain from damage. In adults, the major causes of brain damage are aging and dementia. The most prominent dementia, and the condition that grabs the most public attention, is Alzheimer's disease. T...

journal_title：Neurobiology of aging

authors： Cooper JK

更新日期：2014-09-01 00:00:00

abstract：:Extracellular deposit of amyloid beta (Aβ) is a common pathologic feature in both age-related macular degeneration (AMD) and Alzheimer's disease, but the role of intracellular Aβ on the tight junction of the retinal pigment epithelium (RPE) is unknown. In this study, we investigated the intracellular Aβ expression and...

journal_title：Neurobiology of aging

authors： Park SW,Kim JH,Mook-Jung I,Kim KW,Park WJ,Park KH,Kim JH

更新日期：2014-09-01 00:00:00

abstract：:Age-related changes in the default-mode network (DMN) have been identified in prior cross-sectional functional magnetic resonance imaging studies. Here, we investigated longitudinal change in DMN activity and connectivity. Cognitively intact participants (aged 49-79 years at baseline) were scanned twice, with a 6-year...

journal_title：Neurobiology of aging

authors： Persson J,Pudas S,Nilsson LG,Nyberg L

更新日期：2014-09-01 00:00:00

abstract：:We identified neural correlates of declined and preserved basic visual attention functions in aging individuals based on Bundesen "Theory of Visual Attention". In an interindividual difference approach, we contrasted electrophysiology of higher- and lower-performing younger and older participants. In both age groups, ...

journal_title：Neurobiology of aging

authors： Wiegand I,Töllner T,Dyrholm M,Müller HJ,Bundesen C,Finke K

更新日期：2014-09-01 00:00:00

abstract：:The mechanism by which amyloid beta (Aβ) causes neuronal dysfunction and/or death in Alzheimer's disease (AD) is unclear. Previously, we showed that Aβ inhibits several microtubule-dependent kinesin motors essential for mitosis and also present in mature neurons. Here, we show that inhibition of kinesin 5 (Eg5) by Aβ ...

journal_title：Neurobiology of aging

authors： Ari C,Borysov SI,Wu J,Padmanabhan J,Potter H

更新日期：2014-08-01 00:00:00

abstract：:Increased age is a major risk factor for stroke incidence and post-ischemic mortality. To develop age-adjusted therapeutic interventions, a clear understanding of the complexity of age-related post-ischemic mechanisms is essential. Transient occlusion of the middle cerebral artery--a model that closely resembles human...

journal_title：Neurobiology of aging

authors： Sieber MW,Guenther M,Jaenisch N,Albrecht-Eckardt D,Kohl M,Witte OW,Frahm C

更新日期：2014-07-01 00:00:00

abstract：:White matter is frequently involved in ischemic stroke, and progressive ischemic white matter injuries are associated with various neurologic dysfunctions in the elderly population. Demyelination and oligodendrocyte (OL) loss are prominent features of ischemic white matter injury. Endothelin-1 injection into the inter...

journal_title：Neurobiology of aging

authors： Choi JY,Cui Y,Kang YM,Kim JH,Lee SJ,Kim BG

更新日期：2014-07-01 00:00:00

abstract：:Plasma membrane cellular prion protein (PrP(C)) is a high-affinity receptor for toxic soluble amyloid-β (Aβ) oligomers that mediates synaptic dysfunction. Secreted forms of PrP(C) resulting from PrP(C) α-cleavage (PrPN1) or shedding (shed PrP(C)) display neuroprotective activity in neuronal cultures and in mouse model...

journal_title：Neurobiology of aging

authors： Béland M,Bédard M,Tremblay G,Lavigne P,Roucou X

更新日期：2014-07-01 00:00:00

abstract：:Nonhuman primates (NHPs) are useful for the study of age-associated changes in the brain as a model that is biologically closely related to humans. For example, with age, all NHPs analyzed to date, develop β-amyloid (Aβ) plaques as seen in humans. Nevertheless, it is still unclear if NHPs have human-like age-associate...

journal_title：Neurobiology of aging

authors： Yue F,Lu C,Ai Y,Chan P,Zhang Z

更新日期：2014-07-01 00:00:00

abstract：:Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease after the age of 40 years. To detect white matter (WM) changes in the brain linked to dementia, fractional anisotropy (FA) from diffusion tensor imaging was used. We hypothesized that adults with DS without dementia (DS n = 10), DS with...

journal_title：Neurobiology of aging

authors： Powell D,Caban-Holt A,Jicha G,Robertson W,Davis R,Gold BT,Schmitt FA,Head E

更新日期：2014-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving the progressive degeneration of motor neurons in the brain and spinal cord. Mitochondrial dysfunction plays a key role in ALS disease progression and has been observed in several ALS cellular and animal models. Here, we show that fibro...

journal_title：Neurobiology of aging

authors： Allen SP,Rajan S,Duffy L,Mortiboys H,Higginbottom A,Grierson AJ,Shaw PJ

更新日期：2014-06-01 00:00:00

abstract：:Elevated expression of human hyperphosphorylated tau is associated with neuronal loss and white matter (WM) pathology in Alzheimer's disease (AD) and related neurodegenerative disorders. Using in vivo diffusion tensor magnetic resonance imaging (DT-MRI) at 11.1 Tesla we measured age-related alterations in WM diffusion...

journal_title：Neurobiology of aging

authors： Sahara N,Perez PD,Lin WL,Dickson DW,Ren Y,Zeng H,Lewis J,Febo M

更新日期：2014-06-01 00:00:00

abstract：:Age-related cognitive decline is a major public health concern facing a large segment of the US population. To identify genetic risk factors related to cognitive decline, we used nationally representative longitudinal data from the US Health and Retirement Study to conduct genome-wide association studies with 5765 par...

journal_title：Neurobiology of aging

authors： Zhang C,Pierce BL

更新日期：2014-06-01 00:00:00

abstract：:As a major characteristic of aging process, neuroinflammation is involved in the pathogenesis of several aging-related diseases including Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2) is a newly identified risk gene for AD, which regulates inflammatory process in peripheral tissues...

journal_title：Neurobiology of aging

authors： Jiang T,Yu JT,Zhu XC,Tan MS,Gu LZ,Zhang YD,Tan L

更新日期：2014-06-01 00:00:00

abstract：:Although the neurodevelopment of empathy from childhood to adolescence has been documented, no study has yet examined it across a life span aging perspective. Sixty-five healthy participants from 3 age groups (young, middle-aged, old) underwent functional magnetic resonance imaging while presented with visual stimuli ...

journal_title：Neurobiology of aging

authors： Chen YC,Chen CC,Decety J,Cheng Y

更新日期：2014-04-01 00:00:00

abstract：:Cholesterol is implicated in the development of late-onset Alzheimer's disease (AD). We sought to determine the associations between beta amyloid (Aβ) plaque deposition in vivo using Pittsburgh compound B (PiB) and several indices of cholesterol homeostasis (i.e., total cholesterol, high-density lipoprotein cholestero...

journal_title：Neurobiology of aging

authors： Hughes TM,Lopez OL,Evans RW,Kamboh MI,Williamson JD,Klunk WE,Mathis CA,Price JC,Cohen AD,Snitz BE,Dekosky ST,Kuller LH

更新日期：2014-04-01 00:00:00

abstract：:A recent genome-wide association study of patients with essential tremor (ET) from Germany has nominated SLC1A2 rs3794087 as a novel risk factor for disease. This association was independently replicated in the Chinese population, albeit with an opposite direction of effect. To further define the role of SLC1A2 in ET,...

journal_title：Neurobiology of aging

authors： Ross JP,Rayaprolu S,Bernales CQ,Soto-Ortolaza AI,van Gerpen J,Uitti RJ,Wszolek ZK,Rajput A,Rajput AH,Rajput ML,Ross OA,Vilariño-Güell C

更新日期：2014-04-01 00:00:00

abstract：:Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with ε4 correlated with shorter life, and ε2 with longer life, than ε3. We hypothesized that rare APOE variants with large individual effects might also contribute to long-term good health. The APOE exons and promoter were resequenced ...

journal_title：Neurobiology of aging

authors： Tindale LC,Leach S,Ushey K,Daley D,Brooks-Wilson AR

更新日期：2014-03-01 00:00:00

abstract：:Kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) play a key role in relaying the positive feedback effects of estradiol that activate gonadotropin-releasing hormone (GnRH) neurons and drive a surge in the GnRH/luteinizing hormone (LH) level. However, the precise role of kisspeptin n...

journal_title：Neurobiology of aging

authors： Zhang J,Yang L,Lin N,Pan X,Zhu Y,Chen X

更新日期：2014-03-01 00:00:00

abstract：:Accumulating evidence suggests that glycogen synthase kinase 3 (GSK-3) is a multifunctional kinase implicated in Alzheimer's disease (AD). However, the synaptic actions of GSK-3 in AD conditions are largely unknown. In this study, we examined the impact of GSK-3 on N-methyl-D-aspartate receptor (NMDAR) channels, the m...

journal_title：Neurobiology of aging

authors： Deng Y,Xiong Z,Chen P,Wei J,Chen S,Yan Z

更新日期：2014-03-01 00:00:00

abstract：:Oxidative stress is believed to be a significant cause of Parkinson's disease (PD). DJ-1 is thought to be an oxidative sensor that protects cells from oxidative insult. It was reported that the level of total DJ-1 protein was significantly reduced in the substantia nigra of sporadic PD patients, suggesting that abnorm...

journal_title：Neurobiology of aging

authors： Xiong R,Wang Z,Zhao Z,Li H,Chen W,Zhang B,Wang L,Wu L,Li W,Ding J,Chen S

更新日期：2014-03-01 00:00:00

abstract：:Superficial layers I to III of the human cerebral cortex are more vulnerable toward Aβ peptides than deep layers V to VI in aging. Three models of layers were used to investigate this pattern of frailty. First, primary neurons from E14 and E17 embryonic murine cortices, corresponding respectively to future deep and su...

journal_title：Neurobiology of aging

authors： Fugistier P,Vallet PG,Leuba G,Piotton F,Marin P,Bouras C,Savioz A

更新日期：2014-02-01 00:00:00

abstract：:Abberant lipid metabolism is implicated in Alzheimer's disease (AD) pathophysiology, but the connections between AD and lipid metabolic pathways are not fully understood. To investigate plasma lipids in AD, a multiplatform screen (n = 35 by liquid chromatography-mass spectrometry and n = 35 by nuclear magnetic resonan...

journal_title：Neurobiology of aging

authors： Whiley L,Sen A,Heaton J,Proitsi P,García-Gómez D,Leung R,Smith N,Thambisetty M,Kloszewska I,Mecocci P,Soininen H,Tsolaki M,Vellas B,Lovestone S,Legido-Quigley C,AddNeuroMed Consortium.

更新日期：2014-02-01 00:00:00

abstract：:The senescence-accelerated mouse (SAMP8) strain exhibits decreased learning and memory and increased amyloid beta (Aβ) peptide accumulation at 12 months. To detect differences in gene expression in SAMP8 mice, we used a control mouse that was a 50% cross between SAMP8 and CD-1 mice and which showed no memory deficits ...

journal_title：Neurobiology of aging

authors： Armbrecht HJ,Siddiqui AM,Green M,Farr SA,Kumar VB,Banks WA,Patrick P,Shah GN,Morley JE

更新日期：2014-01-01 00:00:00

abstract：:Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a potential to preclude the generation of Aβ because it occurs within the A...

journal_title：Neurobiology of aging

authors： Ohno M,Hiraoka Y,Lichtenthaler SF,Nishi K,Saijo S,Matsuoka T,Tomimoto H,Araki W,Takahashi R,Kita T,Kimura T,Nishi E

更新日期：2014-01-01 00:00:00

abstract：:Abnormal neuronal excitability and impaired synaptic plasticity might occur before the degeneration and death of neurons in Alzheimer's disease (AD). To elucidate potential biophysical alterations underlying aberrant neuronal network activity in AD, we performed whole-cell patch clamp analyses of L-type (nifedipine-se...

journal_title：Neurobiology of aging

authors： Wang Y,Mattson MP

更新日期：2014-01-01 00:00:00

abstract：:Studies regarding different viruses of the herpes family, such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), or human herpes virus 6 (HHV-6) in Alzheimer's disease (AD) are scarce. DNA from peripheral blood leukocytes (PBL) and brain samples were analyzed for the presence of CMV, EBV, or HHV-6. All samples were ...

journal_title：Neurobiology of aging

authors： Carbone I,Lazzarotto T,Ianni M,Porcellini E,Forti P,Masliah E,Gabrielli L,Licastro F

更新日期：2014-01-01 00:00:00

abstract：:The development of amyloid imaging compounds has allowed in vivo imaging of amyloid deposition. In this study, we examined the spatial patterns of amyloid deposition throughout the brain using Pittsburgh Compound Blue ((11)C-PiB) positron emission tomography data from the Baltimore Longitudinal Study of Aging. We used...

journal_title：Neurobiology of aging

authors： Yotter RA,Doshi J,Clark V,Sojkova J,Zhou Y,Wong DF,Ferrucci L,Resnick SM,Davatzikos C

更新日期：2013-12-01 00:00:00

abstract：:The abnormal accumulation of amyloid fibrils in the brain is pathognomonic of Alzheimer's disease. Amyloid fibrils induce significant neuroinflammation characterized by the activation of microglia and impairment of synaptic plasticity in the brain that eventually leads to cognitive decline. Chemokine fractalkine recep...

journal_title：Neurobiology of aging

authors： Wu J,Bie B,Yang H,Xu JJ,Brown DL,Naguib M

更新日期：2013-12-01 00:00:00

abstract：:Previous studies have shown that affective symptoms are part of the clinical picture in amyotrophic lateral sclerosis (ALS), the most common motor neuron disorder in elderly people. Diffuse neurodegeneration of limbic regions (e.g., prefrontal cortex [PFC], amygdala) was demonstrated in ALS post-mortem, although the m...

journal_title：Neurobiology of aging

authors： Passamonti L,Fera F,Tessitore A,Russo A,Cerasa A,Gioia CM,Monsurrò MR,Migliaccio R,Tedeschi G,Quattrone A

更新日期：2013-11-01 00:00:00

abstract：:Neurogenesis persists in the adult brain as a form of plasticity due to the existence of neural stem cells (NSCs). Alterations in neurogenesis have been found in transgenic Alzheimer's disease (AD) mouse models, but NSC activity and neurogenesis in sporadic AD models remains to be examined. We herein describe a remark...

journal_title：Neurobiology of aging

authors： Díaz-Moreno M,Hortigüela R,Gonçalves A,García-Carpio I,Manich G,García-Bermúdez E,Moreno-Estellés M,Eguiluz C,Vilaplana J,Pelegrí C,Vilar M,Mira H

更新日期：2013-11-01 00:00:00